Real fought back after a calamitous own goal from keeper Keylor Navas gave Betis the lead in the 25th minute, just after the Costa Rican escaped a possible red card. Cristiano Ronaldo pulled the hosts level in the 41st with a diving header.
Fresh from propelling Barcelona to their fifth trophy of 2015, their prolific strikes are now seeking to break the Spanish record of goals in a calendar year when they play Real Betis on Wednesday.
'I haven't lost any strength in the last four days and in one sense I feel a little relieved but focused on the objectives we set for ourselves at the start of the season'
Valencia climbed above Atletico Madrid and Sevilla into third in La Liga when Alvaro Negredo came off the bench to score a late winner in a 3-2 home victory over his former club Almeria on Saturday.
Argentina's Lionel Messi and Carlos Tevez, English third tier player David Hall and U.S. women's international Carli Lloyd were among players included on the shortlist for FIFA's goal of the year award on Friday.
"The intention is to sell him, but there's no offers forthcoming," read the front page of Marca, accompanied by a picture of the 29-year-old Bale looking sullen.
Cristian Tello hit a hat-trick as Barcelona came from behind to win 4-1 in their King's Cup quarter-final first leg at Levante on Wednesday and Lionel Messi celebrated his 400th appearance for the Catalan side.
Ballon d'Or winner Cristiano Ronaldo scored the opening goal as 10-man Real Madrid beat Osasuna 2-0 on Wednesday to qualify for the King's Cup quarter-finals 4-0 on aggregate.
Pierre-Emerick Aubameyang scored twice as a rejuvenated Barcelona gave a football masterclass to inflict a humiliating 4-0 defeat on rivals Real Madrid on Sunday.
Lionel Messi will be working "full time" to shake off the hamstring injury sustained on Sunday that will sideline him for six to eight weeks, Barcelona's Argentine World Player of the Year said on Tuesday.
La Liga leaders Barcelona beat Real Madrid 1-0 to all but knock their rivals out of the title race on Saturday, while second-placed Atletico Madrid stayed seven points behind the Catalans with a 2-0 win at Real Sociedad on Sunday.
Barcelona coach Luis Enrique was pleased they got straight back into their stride with Tuesday's 2-1 friendly win over the Los Angeles Galaxy.
Here is a quick fact-box on new Real Madrid coach Rafael Benitez, who was appointed to replace Italian Carlo Ancelotti on Wednesday.
Barcelona midfielder and captain Xavi confirmed on Thursday he will leave his boyhood club at the end of the season and has agreed to join Qatari side Al Sadd after a glittering career stretching over 17 seasons.
Barcelona midfielder Xavi will announce on Thursday he is leaving the club he joined as an 11-year-old to sign a lucrative three-year deal with Qatari side Al Sadd, his agent told Reuters on Wednesday.
Stopping prolific Barcelona forwards Lionel Messi, Neymar and Luis Suarez in the Champions League final will be a formidable task, Juventus coach Massimiliano Allegri said after his side clinched their place in next month's showpiece in Berlin.
Barcelona's Lionel Messi, Luis Suarez and Neymar motored past 100 goals for the season.
Barcelona's outlay of 20 million euros ($22 million) on Jeremy Mathieu last July prompted plenty of criticism but the France centre back has been worth his weight in gold in the La Liga leaders' last two outings.
Outgoing Spain coach Vicente del Bosque has no regrets as he prepares to leave his post at the end of July after eight years in charge during which they won the World Cup and Euro 2012.
Cristiano Ronaldo's bullet header helped Real Madrid to a 2-0 victory .
Neymar struck twice as Barca beat Atletico Madrid to reach the King's Cup semis
Real Madrid made it two wins in two La Liga outings this season when Karim Benzema's scuffed 10th-minute strike secured an uninspiring 1-0 win at Granada on Monday.
Juergen Klopp, who has breathed new life into Liverpool in his seven months in charge, would seal his place in the hearts of the club's supporters if he pulls off victory over Sevilla in Wednesday's Europa League final.
News of all that's transpired on and off the football field
Inter moved on to 68 points, ahead of Lazio on goal difference as the sides are level on their head-to-head records. They are eight points behind Juventus with six games to play.
Barcelona forward Lionel Messi set a La Liga record of 253 goals when he grabbed a hat-trick in Saturday's 5-1 win at home to Sevilla, the latest milestone for the four-times World Player of the Year.
Real Madrid secured a club record 16th straight victory when Karim Benzema and Gareth Bale struck in a laboured 2-1 win at Malaga on Saturday that put them five points clear of second-placed Barcelona in La Liga.
News of all that's transpired on and off the football field
Federico Valverde finished off a stunning move in extra time to give Real Madrid a 3-2 victory over arch-rivals Barcelona
While Gareth Bale is fully expected to regain his place in the Real Madrid side when he returns from injury, team mate Isco is making the most of his chance to prove his worth on the pitch.
As Barca prepare for a trip to Madrid to play Rayo Vallecano on Saturday, they are still reeling from Tuesday's 3-2 Champions League reverse at Paris St Germain, when their defence was badly exposed by the Ligue 1 title holders.
Lionel Messi scored his 650th goal for Barcelona while Antoine Griezmann struck the winner in a 2-1 home success over Athletic Bilbao
The victory takes Barcelona up to fourth with 10 points after six games, one point behind surprise leaders Granada, Athletic Bilbao, who visit Leganes on Wednesday, and Real Madrid ahead of their game at home to Osasuna the same night.
Barcelona have been frighteningly good at home this season, scoring 15 goals in three games at the Nou Camp.
Barcelona leapfrogged Atletico Madrid to go top of La Liga after Lionel Messi's acrobatic volley secured a hard-fought 2-1 victory against tenacious Malaga on Saturday.
Antoine Griezmann scored twice off the bench as Atletico Madrid sealed a place in the King's Cup quarter-finals with a 3-0 win at home to Rayo Vallecano on Thursday while Valencia also advanced with victory by the same scoreline at Granada.
It is a scenario few could have foreseen after Real won a Liga and Champions League double last term and began this season so convincingly.
Atletico coach Simeone defends VAR for making football fairer
Angry Barcelona coach Luis Enrique blamed stupid mistakes after the La Liga pacesetters threw away a two goal lead to draw 2-2 at home to Deportivo La Coruna on Saturday. Barca have drawn their last two games in La Liga and could see Atletico Madrid draw level with them if they beat Athletic Bilbao on Sunday, ahead of their trip to the Club World Cup in Japan next week.
Marcelino dismissed but Valencia keep pressure on Barcelona